my hs-CRP moved and I cannot work out whether Zepbound is why
Quick one. Canada here.
Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Half-life is about 168 hours, so steady state lands around week 17–5. Practical consequence: what you feel in week 1 is not what that dose does.
the 15mg is the top of the pen, not the required dose
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the appetite change on tirz is more than just reduced hunger, it is different machinery
Disagree on that part. 96.8% and 96.2% on the same vial is normal.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
dual agonism is GIP, do not generalise from semaglutide
SURMOUNT data is messier than STEP data but the weight loss is there
Half-life is about 168 hours, so steady state lands around week 17–5.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Tried both. Sema worked, tirz worked better for me, but my early fullness profile was worse on tirz.
the GIP side does different things than the GLP-1 side, that is the point
stalled on sema, tried tirz, and the curves were actually different shapes
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Week 13 on Mounjaro and 24kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
the 15mg is the top of the pen, not the required dose
Half-life is about 168 hours, so steady state lands around week 4–5. Practical consequence: what you feel in week 1 is not what that dose does.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
the nausea from tirz is different, not necessarily worse
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
The confident tone is doing a lot of work that the evidence is not.
You have restated the marketing copy. What is the actual substance here.
the GIP side does different things than the GLP-1 side, that is the point
Not to be pedantic but GIP and Zepbound are being used interchangeably and they are not interchangeable in real life.
The confident tone is doing a lot of work that the evidence is not.
Disagree on that part. 99.2% and 99.3% on the same vial is normal.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
- 1Half-life is about 168 hours, so steady state lands around week 17–5.…11 comments in this branch · started by u/elin_ferrari
- 2the nausea from tirz is different, not necessarily worse8 comments in this branch · started by u/laila_yilmaz