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c/tirzepatide·submitted 4 months ago by u/tidy_vialdrawer_pls

tried tirzepatide for 23 weeks. here is what happened.

Questionbranch of 8 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking tirzepatide against eGFR for 13 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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8 comments, started 3 months ago
u/incretin_ivyMOD216 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/tidy_vialdrawer_plsOP95 points·3 months ago

Retitled to remove editorialising.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/ewan_marchand23 points·3 months ago

week 35 on Mounjaro and the appetite profile is genuinely different from sema

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u/cormac_pereira11 points·3 months ago

the 15mg is the top of the pen, not the required dose

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u/emil_okwuosa7 points·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/copay_card_cc4 points·3 months ago·edited

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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