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crossposted from c/maintenancephase by u/copay_card_cc — is it normal to get nausea at week 34
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c/trialwatch·posted 10 months ago by u/enzo_ferrari

week 91 check-in — 37kg down, early fullness manageable, one thing confusing me

Trial Data

Week 14 update. 10kg down from the start, early fullness basically gone since about week 54.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

770 up / 801 down50% upvoted12 commentsid 44vzbf6 Sep 2025

12 comments

12 in this archive, depth 3

best — the order this archive was captured in

u/heart_rate_bump2 points·10 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/rania_salinas1 point·10 months ago

the 3 week readout is different from the 9 week readout

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u/yannick_salinas3 points·10 months ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/enzo_ferrariOP4 points·10 months ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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[removed]2 points·10 months ago

[removed by moderator]

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u/adaeze_weiss2 points·10 months ago

the 14 week readout is different from the 16 week readout

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u/heart_rate_bump1 point·10 months ago·edited

Disagree. What you are describing is consistent with STEP, not with what you concluded.

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u/yannick_salinas1 point·10 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/nils_tulloch1 point·10 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/aurel_mwangi1 point·10 months ago

Which trial and what was the primary endpoint?

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u/milos_trevino1 point·10 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/anders_kuusela1 point·10 months ago

Which trial and what was the primary endpoint?

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