[Results] 62 weeks, 45kg, and FLOW was the hard part
Right, the TRIUMPH question again, but with numbers this time.
I have 16 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 66, not week 20. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Retitled to remove editorialising. Put the evidence in the body.
[removed by moderator]
number-needed-to-treat is the house dialect
Yeah, absolute numbers matter more than the press release.
absolute risk reduction, not relative risk reduction, that is how you decide
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
Yeah, absolute numbers matter more than the press release.
press release hazard ratio posts must be flaired until a publication exists
STEP 1 readout: 99.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
phase 2 is not phase 3, smaller n and shorter trial
Phase 2 or phase 3?
the 7 week readout is different from the 28 week readout
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
Yeah, absolute numbers matter more than the press release.
the discontinuation arms are the interesting part, not the STEP endpoints
off-label use data is different from approved-indication data
SURMOUNT-4 discontinuation arm showed regain.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the discontinuation arms are the interesting part, not the endpoint endpoints
Not convinced. The evidence does not support that reading.
give the trial name, phase, n, and primary endpoint in the body
press release STEP posts must be flaired until a publication exists
press release STEP posts must be flaired until a publication exists
Adding to this: SURMOUNT is doing more work than the comment implies.
the 12 week readout is different from the 14 week readout
the 12 week readout is different from the 14 week readout
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
- 1STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix17 comments in this branch · started by u/heart_rate_bump
- 2Retitled to remove editorialising. Put the evidence in the body.5 comments in this branch · started by u/forest_plot_fiona