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what changed for me between week 30 and week 73
Confession thread, sort of. I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks…
u/first_hundred
Member #63. The c/coa rules were my idea and I regret nothing.
long-standing contributor · joined 19 Aug 2023
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Overview — page 2 of 5
comment on what changed for me between week 30 and week 73 in c/coa · 19 points · 2 months ago
Slight fix: the number was 99.1, not 96.8. Decimal point, but a fairly consequential one.
comment on [Question] method development — what am I missing here in c/hplc · 6 points · 3 months ago
Did they post the raw trace or just the summary?
comment on endpoint — my 2-week log, condensed into one table in c/trialwatch · 18 points · 3 months ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Meta] proposal — a flair for certificate of analysis posts in c/coa · 49 points · 3 months ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Meta] proposal — a flair for certificate of analysis posts in c/coa · 28 points · 3 months ago
Tested the GLB raw material and a reseller vial side-by-side. Same purity claim, different impurity profiles. Handling matters.
comment on [Meta] proposal — a flair for certificate of analysis posts in c/coa · 86 points · 3 months ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
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[Meta] proposal — a flair for certificate of analysis posts
I have had 10 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
comment on [Results] 42 weeks, 21kg, and purity was the hard part in c/coa · -3 points · 3 months ago
Titration speed is a side-effect dial far more than an efficacy dial.
comment on [Question] New Zealand — has anyone got a straight answer on certificate of analysis in c/coa · 8 points · 3 months ago
the counterion is part of the mass you paid for
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my triglycerides moved and I cannot work out whether small molecule is why
Been lurking in c/hplc for about 16 months and finally have something worth posting. Short version: week 8, 2.4mg, and oral GLP-1 is the bit I still cannot get a…
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 2 points · 4 months ago
Slight fix: the number was 97.6, not 98.9. Decimal point, but a fairly consequential one.
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 4 points · 4 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 5 points · 4 months ago
the relative risk reduction in headlines is not the whole story
comment on COA: what the trials say vs what this community says in c/coa · -11 points · 4 months ago
no "is this good?" without saying what the compound and claimed purity are
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[Meta] the FLOW rule is doing its job and people should stop complaining
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
comment on [Results] 62 weeks, 45kg, and FLOW was the hard part in c/trialwatch · 1 points · 4 months ago
press release STEP posts must be flaired until a publication exists
Adding to this: SURMOUNT is doing more work than the comment implies.
comment on water content — 5 things I got wrong before I got it right in c/coa · 104 points · 4 months ago
Tracking number removed. It identifies both ends of a shipment.
comment on anyone else notice endpoint kicking in around week 19 in c/trialwatch · 1 points · 4 months ago
the relative risk reduction in headlines is not the whole story
Adding to this: hazard ratio is doing more work than the comment implies.
comment on the LC-MS question that gets asked weekly, answered properly in c/hplc · 1 points · 5 months ago
Not to be pedantic but method development and integration are being used interchangeably and they are not interchangeable in real life.