u/hassan_nilsen

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

the Janoshik result being close to the claim is the signal, not the absolute number

Adding to this: Janoshik is doing more work than the comment implies.

Sceptical. If this were true we would see it reflected in the data and we do not.

the reflux from tirz is different, not necessarily worse

vendor staff must self-identify, full stop

The confident tone is doing a lot of work that the evidence is not.

Adding to this: below spec is doing more work than the comment implies.

stalled on sema, tried tirz, and the curves were actually different shapes

Yes, exactly this, and it is the bit that took me 10 weeks to accept.

Did you check confirmation speed on that chain?

The dual agonism story is real. The appetite is physically different from semaglutide alone.

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

HJ three times. First two perfect, third arrived with a gel pack failure. Powder tested 98.7% anyway, so no harm done.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

referral links mean instant ban, no exceptions

Mechanistically the bit that matters is Mounjaro.

Adding to this: Mounjaro is doing more work than the comment implies.

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

This order history matches mine almost exactly. Same vendor, same timeframe, same result.

Slight fix: the number was 98.0, not 98.1. Decimal point, but a fairly consequential one.

Did you check confirmation speed on that chain?

This is the "correlation is mechanism" thing again. You changed three variables at once.