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c/retatrutide·posted 1 year ago by u/baseline_drifter

triple agonist — 9 things I got wrong before I got it right

Question Clean Column ×7 The Quiet One ×3 Slow Clap ×2

Something I noticed reading old threads that I have not seen said out loud.

The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

24,487 up / 18,245 down57% upvoted32 commentsid 1yrosr20 Feb 2025

32 comments

26 in this archive, depth 6

best — the order this archive was captured in

u/aa_analysis_andy0 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/honest_syringe_20251 point·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/blunt_coldbox_20241 point·1 year ago·edited

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/honest_syringe_20251 point·1 year ago

What was the dosing schedule in that arm?

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u/rui_only_ro612 points·1 year ago

research use only, handling and analysis, not protocols

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u/marta_vanhecke204 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/ewan_zielinski353 points·1 year ago

triple agonism is TRIUMPH, do not generalise

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u/divya_bakken234 points·1 year ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/hassan_nilsen63 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/source_or_silence153 points·1 year ago·edited

the weight curves are unusually steep, which makes predicting individual response harder

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u/yannick_barros328 points·1 year ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/marit_laurent225 points·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/soren_nkemelu168 points·1 year ago

nobody should be giving this to anyone without extensive monitoring

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[deleted]124 points·1 year ago

[deleted]

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u/baseline_drifterOPanalytical55 points·1 year ago

Which trial arm and what was the n?

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u/janek_ferrari245 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/reflux_report159 points·1 year ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/reta_and_regretMOD107 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/solene_ilunga0 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/yusuf_ramos-7 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/reflux_report1 point·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/careful_gradient_notes1 point·1 year ago

research use only, handling and analysis, not protocols

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u/rekha_vestergaard1 point·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/marta_vanhecke1 point·1 year ago

nobody should be giving this to anyone without extensive monitoring

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u/careful_gradient3229 points·1 year ago

Removed a chain here.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/careful_gradient_notes101 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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