u/rasmus_kimani

near-zero controlled human data, full stop

Slight fix: the number was 96.8, not 98.0. Decimal point, but a fairly consequential one.

Strongly agree.

Adding to this: A1c is doing more work than the comment implies.

the two-year waiting list is accurate for most of England

The half-life is 13 hours, which means week 13 is genuinely still ramp-up. Week 12 is steady state.

Came off after 49 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

the sequence variation is the real issue

co-elution is real and gradient is usually not enough to resolve it

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

incretin physiology is pharmacology, the mechanism layer

This is correct. Private and NHS pathways are different.

How many weeks between the two measurements?

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

Yeah, text-only removes the comparison.

week 91 on the pen, 12kg down, this is the answer

handlers in the community are rare and cautious

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

the lesson is the point

stalled at 5mg, went up, and regretted it, the stall would have broken anyway