u/tarek_kirchner

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

dual agonism is SURPASS, do not generalise from semaglutide

the 15mg is the top of the pen, not the required dose

Adding to this: SURPASS is doing more work than the comment implies.

stalled on sema, tried tirz, and the curves were actually different shapes

Hard agree. The food noise disappears differently on the two compounds.

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

week 13 on Mounjaro and the appetite profile is genuinely different from sema

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

The dual agonism story is real. The appetite is physically different from semaglutide alone.

Zepbound and Mounjaro are literally the same drug, the name is the only difference

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

This matches the trial data. SURMOUNT-1 was 99.2% body weight at 11 weeks.

Hard agree. The food noise disappears differently on the two compounds.

the 15mg is the top of the pen, not the required dose

This matches the trial data. SURMOUNT-1 was 96.2% body weight at 6 weeks.

do not crack the pen, we have been over this

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

dual agonism is GIP, do not generalise from semaglutide

Zepbound and Mounjaro are literally the same drug, the name is the only difference

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.