u/yusuf_ramos

This is correct. Triple agonism is genuinely different.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

the relative risk reduction in headlines is not the whole story

retatrutide is not approved anywhere for human use, posts must not read as instructions

Maintenance for 5 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

Hard agree. The food noise disappears differently on the two compounds.

Strongly agree. Heart rate escalation needs the actual data, not impressions.

failures, regrets, things that went wrong

tests that came back 95.1%

Mechanistically the bit that matters is gastric emptying.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Disagree. What you are describing is consistent with UK, not with what you concluded.

Second this question. I have wondered about lost money for 16 months and never seen a straight answer.

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

Are you quoting phase 2 or is there phase 3 data now?

do not crack the pen, we have been over this

Strongly agree. Central appetite is real but people overstate it.

Crossposting this to c/sideeffects because the people who need it are not reading this community.