the retatrutide question that gets asked weekly, answered properly
Something I noticed reading old threads that I have not seen said out loud.
The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
This is the "correlation is mechanism" thing again. You changed three variables at once.
This is correct. Triple agonism is genuinely different.
Retitled to remove editorialising. Put the evidence in the body.
This is correct. Triple agonism is genuinely different.
phase 2 numbers are not maintenance numbers, cite the trial
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Disagree. What you are describing is consistent with glucagon, not with what you concluded.
the 0.5mg arm is different from 0.25mg, results do not transfer
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
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the dosing is steep, the constipation reports are real, and nobody knows the human safety yet
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
This is correct. Triple agonism is genuinely different.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
This is correct. Triple agonism is genuinely different.
TRIUMPH phase 2 showed 98.0% weight loss but the the food-noise thing profile on the highest arm was rough. Phase 2 != phase 3.
heart rate and dose escalation need actual measurements, not impressions
This is correct.
Yes, exactly this, and it is the bit that took me 52 weeks to accept.
- 1The practical rule people converge on is 28 days at fridge temperature after…6 comments in this branch · started by u/nadia_norgaard
- 2Retitled to remove editorialising. Put the evidence in the body.4 comments in this branch · started by u/reta_and_regret