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c/bloodwork·posted 6 months ago by u/whois_wanda

anyone else notice bloodwork kicking in around week 75

Baseline Sourced ×9

eGFR. That is the whole post, but I will justify it.

Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort eGFR out first, and almost nobody does.

I say this having got it wrong for 24 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

935 up / 272 down77% upvoted33 commentsid 1ykyr412 Jan 2026

33 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/liver_enzyme_liz73 points·6 months ago

nobody here can tell you what a result means for you

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u/emeka_chowdhury48 points·6 months ago

Respectfully this is a sample of one presented as a finding.

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u/nnt_nate33 points·6 months ago

ApoB over LDL-C, that is the hierarchy

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u/yara_mensah16 points·6 months ago

redact identifying details from lab PDFs before posting

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u/cormac_erdogan-5 points·6 months ago

Yeah, baseline matters more than any later number.

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u/emil_agyeman1 point·6 months ago

the 20 month bloodwork check is the routine

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u/copay_card_cc1 point·6 months ago

eGFR from 6 to 19 is movement, not noise

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u/step_therapy_s13 points·6 months ago

ferritin tanks quietly on a reduced appetite, check it

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u/whois_wandaOP36 points·6 months ago

nobody here can tell you what a result means for you

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/thermal_mass_tom28 points·6 months ago

ALT is where the fatty-liver story shows up first

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u/customs_seizure_sid16 points·6 months ago

nobody here can tell you what a result means for you Counter-anecdote: opposite result, same dose.

Yes, exactly this, and it is the bit that took me 47 weeks to accept.

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u/noor_cardoso35 points·6 months ago

I am going to push back on this slightly.

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u/liver_enzyme_liz32 points·6 months ago

A1c moves slowly, quarterly is plenty

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u/rekha_mwangi21 points·6 months ago

the 16 month eGFR check is the routine

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[deleted]13 points·6 months ago

[deleted]

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u/elise_grimaldi8 points·6 months ago

redact identifying details from lab PDFs before posting

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u/micro_bump_mick15 points·6 months ago

A1c moves slowly, quarterly is plenty

Yes, exactly this, and it is the bit that took me 26 weeks to accept.

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u/bac_water_banditreconstitution12 points·6 months ago

ApoB over LDL-C, that is the hierarchy

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u/employer_carveout21 points·6 months ago

Baseline fasting insulin: 98.9. Week 86: 98.6. Same lab, fasted, same time of day. Trend matters.

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u/whois_wandaOP13 points·6 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/cold_chromatogram3114 points·6 months ago

Crossposting this to c/reconstitution because the people who need it are not reading this community.

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u/lipid_panel_larrybloodwork21 points·6 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/whois_wandaOP16 points·6 months ago

ferritin tanks quietly on a reduced appetite, check it

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u/britt_marchand9 points·6 months ago

A1c moves slowly, quarterly is plenty

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u/sanne_novak20 points·6 months ago

Do you have baseline to compare to?

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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