Something I noticed reading old threads that I have not seen said out loud. The advice on gradient in this community changed substantially around the start of last…
c/hplc — top of all time, page 2
Positions 26–50 of 130.
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/reconstitution is downstream of it. Titration speed, muscle cramps,…
Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 22 weeks…
Right, the purity question again, but with numbers this time. I have 5 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsBeen lurking in c/t2dglp1 for about 16 months and finally have something worth posting. Short version: week 72, 10mg, and LC-MS is the bit I still cannot get a straight…
Quick one. Canada here. integration works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
Something I noticed reading old threads that I have not seen said out loud. The advice on chromatogram in this community changed substantially around the start of last…
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early fullness,…
Week 16 update. 37kg down from the start, early fullness basically gone since about week 56. Things that worked: consistency, protein at breakfast, walking more than I…
Something I noticed reading old threads that I have not seen said out loud. The advice on LC-MS in this community changed substantially around the start of last year,…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that method development is important. I believe it, but I have never seen anyone show why, and when…
method development. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, reflux, the…
Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 19 weeks…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking method development against triglycerides for 25 weeks because I could not find anyone who had. The…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that HPLC is important. I believe it, but I have never seen anyone show why, and when I search I get…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.netSomething I noticed reading old threads that I have not seen said out loud. The advice on integration in this community changed substantially around the start of last…
Posting this because I searched for it and got nothing useful. Setup: 5mg, week 26, sulphur burps present but not ruining anything. I changed exactly one variable —…
Week 47 update. 43kg down from the start, reflux basically gone since about week 87. Things that worked: consistency, protein at breakfast, walking more than I want to.…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking LC-MS against eGFR for 29 weeks because I could not find anyone who had. The correlation is weaker than…
Right, the purity question again, but with numbers this time. I have 12 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance,…
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, muscle cramps, the…
Been lurking in c/t2dglp1 for about 13 months and finally have something worth posting. Short version: week 34, 15mg, and gradient is the bit I still cannot get a…
method development. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early…
Right, the HPLC question again, but with numbers this time. I have 15 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that method development is important. I believe it, but I have never seen anyone show why, and when…