is it normal to get constipation at week 29
Confession thread, sort of.
I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 27 reads it before doing the same thing.
best — the order this archive was captured in
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Retitled to remove editorialising. Put the evidence in the body.
Cored the stopper on my 22th draw because I kept using the same entry point. Rotate the puncture site.
Dead space ate 17 units on a low-volume draw. Tiny impact at 0.25mg, massive impact at 15mg.
Dead space ate 17 units on a low-volume draw.
Yes, exactly this, and it is the bit that took me 58 weeks to accept.
Dead space ate 17 units on a low-volume draw.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
dosing errors come from people reconstituting two vials differently and forgetting which is which
dosing errors come from people reconstituting two vials differently and forgetting which is which
Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.
the concentration on the vial in marker is the most important step
This is correct. 2mL versus 11mL is the common mistake.
This is correct. 2mL versus 22mL is the common mistake.
Cosigning. The concentration on the vial in marker is load-bearing.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Slight fix: the number was 98.7, not 99.3. Decimal point, but a fairly consequential one.
swirl, do not shake, or you are courting oxidation
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
Disagree. What you are describing is consistent with dead space, not with what you concluded.
The confident tone is doing a lot of work that the evidence is not.
never post a calculation as advice without stating the concentration
Is that 10mg vial or 21mg?
u-100 syringe, not u-40, or your math is off by factor of 2
i am begging people to write down the concentration
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
15mg vial, 2mL water, concentration is 15/2 — write it on the vial afterwards
Spent 8 weeks confused about concentration math until someone showed me the table. 15mg, 1mL, concentration is 15/1.
never post a calculation as advice without stating the concentration
- 1Water content matters more than people think. If a vial is carrying residual…9 comments in this branch · started by u/arne_restrepo
- 2swirl, do not shake, or you are courting oxidation5 comments in this branch · started by u/cesar_ivaturi