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c/retatrutide·posted 1 year ago by u/emil_wojcik

[Discussion] can we stop arguing about phase 2 until somebody posts a number

Discussion

Something I noticed reading old threads that I have not seen said out loud.

The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

261 up / 88 down75% upvoted18 commentsid 140s5d25 Jul 2025

18 comments

13 in this archive, depth 3

best — the order this archive was captured in

u/trialwatch_theoMOD28 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/emil_wojcikOP17 points·1 year ago

This is an urgent-care question wearing a forum question's clothes.

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/halima_mbeki7 points·1 year ago

I am going to push back on this slightly.

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u/incretin_ivypharmacology20 points·1 year ago

The glucagon component does different things than dual agonism. The the food-noise thing are not just amplified versions.

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u/nadia_norgaard6 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/heart_rate_bump11 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/cold_chromatogram_only7 points·1 year ago

What was the dosing schedule in that arm?

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u/titration_marshalmod · c/semaglutide9 points·1 year ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/nadia_norgaard11 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ewan_zielinski-34 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/marta_vanhecke9 points·1 year ago·edited

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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[deleted]4 points·1 year ago

[deleted]

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u/deleted_my_history3 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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