is it normal to get fatigue at week 90
Quick one. Canada here.
glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Strongly agree. Heart rate escalation needs the actual data, not impressions.
What was the dosing schedule in that arm?
research use only, handling and analysis, not protocols
the glucagon component changes the side effect profile, not just the efficacy
the 5mg arm is different from 2.5mg, results do not transfer
the 1.7mg arm is different from 2.4mg, results do not transfer
Not convinced. The evidence does not support that reading.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the weight curves are unusually steep, which makes predicting individual response harder
Sceptical. If this were true we would see it reflected in the data and we do not.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
This is an urgent-care question wearing a forum question's clothes.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
Not to be pedantic but TRIUMPH and retatrutide are being used interchangeably and they are not interchangeable in real life.
the glucagon component changes the side effect profile, not just the efficacy
the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet
This is correct. Triple agonism is genuinely different.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
research use only, handling and analysis, not protocols
Strongly agree. Heart rate escalation needs the actual data, not impressions.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
triple agonism is glucagon, do not generalise
Strongly agree. Heart rate escalation needs the actual data, not impressions.
I am going to push back on this slightly.
the dosing is steep, the nausea reports are real, and nobody knows the human safety yet
Strongly agree. Heart rate escalation needs the actual data, not impressions.
- 1This is an urgent-care question wearing a forum question's clothes. Please…7 comments in this branch · started by u/ledger_mod
- 2Rodent data is rodent data. Dose scaling is not linear and the models tell…7 comments in this branch · started by u/baseline_drifter