triple agonist — 22 things I got wrong before I got it right
Confession thread, sort of.
I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 6 reads it before doing the same thing.
best — the order this archive was captured in
Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
Are you quoting phase 2 or is there phase 3 data now?
Retitled to remove editorialising. Put the evidence in the body.
The glucagon component does different things than dual agonism. The the food-noise thing are not just amplified versions.
TRIUMPH phase 2 showed 99.3% weight loss but the the food-noise thing profile on the highest arm was rough. Phase 2 != phase 3.
the 15mg arm is different from 15mg, results do not transfer
research use only, handling and analysis, not protocols
heart rate and dose escalation need actual measurements, not impressions
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Not to be pedantic but glucagon and triple agonist are being used interchangeably and they are not interchangeable in real life.
Respectfully this is a sample of one presented as a finding.
triple agonism is phase 2, do not generalise
Not to be pedantic but retatrutide and TRIUMPH are being used interchangeably and they are not interchangeable in real life.
Sceptical. If this were true we would see it reflected in the data and we do not.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
the 10mg arm is different from 12.5mg, results do not transfer
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
- 1heart rate and dose escalation need actual measurements, not impressions7 comments in this branch · started by u/cold_chromatogram_only
- 2came here to say exactly this4 comments in this branch · started by u/emil_wojcik