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c/retatrutide·submitted 23 days ago by u/trialwatch_theo

[PSA] dose escalation is not what most of this community thinks it is

Discussionbranch of 11 comments

Right, the triple agonist question again, but with numbers this time. I have 24 data points over 22 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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11 comments, started 22 days ago
u/aa_analysis_andy65 points·22 days ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/signe_villalobos32 points·22 days ago

TRIUMPH phase 2 showed 98.7% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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u/arne_amankwah15 points·22 days ago

Disagree. What you are describing is consistent with triple agonist, not with what you concluded.

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u/fabio_lehtinen8 points·21 days ago

triple agonism is phase 2, do not generalise

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u/ewan_marchand2 points·21 days ago·edited

The confident tone is doing a lot of work that the evidence is not.

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u/baseline_drifteranalytical30 points·21 days ago

Are you quoting phase 2 or is there phase 3 data now?

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u/trialwatch_theoOPtrial nerd12 points·21 days ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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