[PSA] dose escalation is not what most of this community thinks it is
Right, the triple agonist question again, but with numbers this time.
I have 24 data points over 22 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 26, not week 75. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
the 12.5mg arm is different from 15mg, results do not transfer
triple agonism is phase 2, do not generalise
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
nobody should be giving this to anyone without extensive monitoring
Strongly agree. Heart rate escalation needs the actual data, not impressions.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
TRIUMPH phase 2 showed 98.7% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.
Disagree. What you are describing is consistent with triple agonist, not with what you concluded.
triple agonism is phase 2, do not generalise
The confident tone is doing a lot of work that the evidence is not.
retatrutide is not approved anywhere for human use, posts must not read as instructions
the glucagon component changes the side effect profile, not just the efficacy
the glucagon component changes the side effect profile, not just the efficacy
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
Are you quoting phase 2 or is there phase 3 data now?
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Are you quoting phase 2 or is there phase 3 data now?
Yes, exactly this, and it is the bit that took me 93 weeks to accept.
The glucagon component does different things than dual agonism. The fatigue are not just amplified versions.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the 10mg arm is different from 12.5mg, results do not transfer
Did you actually measure heart rate or is that a feeling?
Strongly agree. Heart rate escalation needs the actual data, not impressions.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
- 1Strongly agree. Heart rate escalation needs the actual data, not impressions.11 comments in this branch · started by u/aa_analysis_andy
- 2the 12.5mg arm is different from 15mg, results do not transfer7 comments in this branch · started by u/quiet_moderator