the glucagon question that gets asked weekly, answered properly
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 20 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…
Disagree but this is the good kind of wrong — it is specific enough to be checked.
triple agonism is phase 2, do not generalise
Not to be pedantic but TRIUMPH and phase 2 are being used interchangeably and they are not interchangeable in real life.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
Not to be pedantic but TRIUMPH and phase 2 are being used interchangeably and they are not interchangeable in real life.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
Did you actually measure heart rate or is that a feeling?
the weight curves are unusually steep, which makes predicting individual response harder
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the 2.4mg arm is different from 1.7mg, results do not transfer
Not convinced. The evidence does not support that reading.