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c/retatrutide·submitted 1 months ago by u/nadia_norgaard

the glucagon question that gets asked weekly, answered properly

Trial Databranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 20 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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9 comments, started 1 months ago
u/endotoxin_elliemicro328 points·1 months ago

Did you actually measure heart rate or is that a feeling?

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u/andres_sorensen126 points·1 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/incretin_ivypharmacology57 points·1 months ago·edited

What was the dosing schedule in that arm?

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u/nadia_norgaard0 points·1 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/cormac_roos1 point·1 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: triple agonist is doing more work than the comment implies.

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u/trialwatch_theotrial nerd106 points·1 months ago

Did you actually measure heart rate or is that a feeling?

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u/nadia_norgaardOP240 points·1 months ago

Are you quoting phase 2 or is there phase 3 data now?

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
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  9. Be recognisably decent. Disagree hard, insult nobody.
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