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c/retatrutide·posted 5 months ago by u/emil_wojcik

[Lab] 14th independent test on QSC, and the trend is the interesting part

Lab Clean Column ×8 Receipts ×1 Sourced ×3

Right, the triple agonist question again, but with numbers this time.

I have 19 data points over 4 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 58, not week 12. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

6,739 up / 2,350 down74% upvoted41 commentsid x0u8f59 Feb 2026

41 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/helga_vermeulen674 points·5 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/mateusz_mensah454 points·5 months ago

research use only, handling and analysis, not protocols

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u/blunt_coldbox_2024124 points·5 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/priya_weiss156 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/viktor_laurent588 points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/liver_enzyme_liz140 points·5 months ago

Small correction: the trial was 4 weeks, not 32. Does not change your point but people will quote it.

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u/incretin_ivypharmacology302 points·5 months ago
batch number?
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u/sofia_wikstrom277 points·5 months ago

Which trial arm and what was the n?

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[removed]111 points·5 months ago

[removed by moderator]

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u/cagrilintide_enthusiast73 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/emil_wojcikOP56 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/reflux_report192 points·5 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/burned_once_twice272 points·5 months ago

Respectfully this is a sample of one presented as a finding.

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u/andres_sorensen184 points·5 months ago

Small correction: the trial was 2 weeks, not 10. Does not change your point but people will quote it.

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u/emil_agyeman265 points·5 months ago

Small correction: the trial was 2 weeks, not 10.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/emil_wojcikOP74 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/matias_falk-14 points·5 months ago

triple agonism is glucagon, do not generalise

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u/farid_molnar1 point·5 months ago·edited

Slight fix: the number was 97.6, not 97.4. Decimal point, but a fairly consequential one.

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u/viktor_laurent1 point·5 months ago

Slight fix: the number was 97.6, not 97.4.

Yes, exactly this, and it is the bit that took me 8 weeks to accept.

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u/reta_and_regret0 points·5 months ago

the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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