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c/survodutide·submitted 2 years ago by u/julia_mensa

reading MASH threads from 2024 and half of it aged badly

Questionbranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against triglycerides for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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5 comments, started 2 years ago
u/renal_outcomes_rnephro-curious-2 points·2 years ago

Yeah, glucagon co-agonism is genuinely different.

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u/trialwatch_theoMOD1 point·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/julia_mensaOP0 points·2 years ago

Came off after 89 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/julia_mensaOP1 point·2 years ago

the MASH indication changes the risk calculus

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u/sofia_ferreira1 point·2 years ago

Phase 20 or 27?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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