[Discussion] the MASH advice in here is 3 years out of date
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking survodutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Sweden here. Waited 16 months on a list, gave up, went private, and the total cost was roughly what I expected.
Which trial arm?
hepatic fat and dual agonist are the story
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Respectfully this is a sample of one presented as a finding.
the safety profile is not just tirzepatide amplified
Yeah, glucagon co-agonism is genuinely different.
the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Half-life is about 168 hours, so steady state lands around week 16–5. Practical consequence: what you feel in week 1 is not what that dose does.
MASH claims need the trial and the biopsy endpoint
Strongly agree. The safety story is separate.
the safety profile is not just tirzepatide amplified
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Poland here. Waited 8 months on a list, gave up, went private, and the total cost was roughly what I expected.
You have restated the marketing copy. What is the actual substance here.
- 1The practical rule people converge on is 28 days at fridge temperature after…7 comments in this branch · started by u/certified_reference
- 2Rodent data is rodent data. Dose scaling is not linear and the models tell…5 comments in this branch · started by u/cato_batista