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c/survodutide·submitted 1 year ago by u/trialwatch_theo

[Meta] proposal — a flair for dual agonist posts

Cautionbranch of 6 comments

Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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6 comments, started 1 year ago
u/rania_marchand23 points·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/tired_ledger_ftw5 points·1 year ago

Hepatic fat or MASH or what?

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u/elin_ferrari8 points·1 year ago

rodent dual agonist is investigation only

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u/sena_teixeira7 points·1 year ago

glucagon co-agonism has a different safety story

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u/teodor_szabo4 points·1 year ago

glucagon co-agonism has a different safety story

Adding to this: survodutide is doing more work than the comment implies.

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u/marisol_frisk5 points·1 year ago

Strongly agree. The safety story is separate.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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