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Single comment threadYou are looking at one branch of genuine question about glucagon that I am slightly embarrassed to ask — 38 comments in the full submission. View in context.
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c/survodutide·submitted 2 years ago by u/sena_teixeira

genuine question about glucagon that I am slightly embarrassed to ask

Paperbranch of 8 comments

Week 17 update. 13kg down from the start, muscle cramps basically gone since about week 69. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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8 comments, started 2 years ago
u/clara_restrepo112 points·2 years ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/hugo_bergstrom47 points·2 years ago

Yeah, glucagon co-agonism is genuinely different.

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u/hub_opssite staff28 points·2 years ago

the heart rate signal is real in the data

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u/nora_ramos33 points·2 years ago

the safety profile is not just tirzepatide amplified

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u/certified_referenceQC26 points·2 years ago

MASH claims need the trial and the biopsy endpoint

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u/cesar_ivaturi19 points·2 years ago

Not to be pedantic but survodutide and biopsy are being used interchangeably and they are not interchangeable in real life.

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u/incretin_ivyMOD82 points·2 years ago

Retitled to remove editorialising. Put the evidence in the body.

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u/sena_teixeiraOP48 points·2 years ago

Maintenance for 17 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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