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c/survodutide·posted 2 years ago by u/honest_syringe_pls

switched from 7.5mg to 5mg and the early fullness got better, not worse

Discussion Cold Box ×1

I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 38 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 96.8% against a claimed 97.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

1,041 up / 310 down77% upvoted55 commentsid 1vt8dc26 Jun 2024

55 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/farid_kuipers136 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/honest_syringe_plsOP59 points·2 years ago

Stalled for 17 weeks, changed nothing, and it started moving again on week 82.

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[removed]39 points·2 years ago

[removed by moderator]

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u/incretin_ivyMOD90 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/milos_mensa56 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/honest_syringe_plsOP23 points·2 years ago

The sulphur burps was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/honest_syringe_plsOP44 points·2 years ago

the MASH indication changes the risk calculus

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u/isabela_nilsen75 points·2 years ago

Strongly agree. The safety story is separate.

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u/jarno_adeyemi55 points·2 years ago

Which trial arm?

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u/renzo_yildiz33 points·2 years ago

Strongly agree. The safety story is separate.

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u/honest_syringe_pls9 points·2 years ago

not approved, descriptive posts only

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u/peak_area_peteanalytical47 points·2 years ago

Which trial arm?

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u/ismael_nwosu29 points·2 years ago

phase 2 data is interesting, phase 28 will be different

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u/nora_oyelaran34 points·2 years ago

phase 20 data is interesting, phase 3 will be different

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u/dexa_twice_yearlybody comp35 points·2 years ago

Which trial arm?

Adding to this: glucagon is doing more work than the comment implies.

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u/renzo_asante59 points·2 years ago

Hepatic fat or MASH or what?

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u/crosspost_bot_no13 points·2 years ago

the GLP-1/glucagon dual is dual agonist, different from GIP/GLP-1

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u/cold_chromatogram_only27 points·2 years ago

Not to be pedantic but biopsy and MASH are being used interchangeably and they are not interchangeable in real life.

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u/elin_tamm26 points·2 years ago·edited

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/rafael_sjoberg24 points·2 years ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/chidi_demir14 points·2 years ago

Mechanistically the bit that matters is glucagon. It explains most of the early profile and a decent chunk of the outcome.

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u/honest_syringe_pls7 points·2 years ago

not approved, descriptive posts only

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u/jarno_adeyemi5 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/meera_sandvik4 points·2 years ago

glucagon co-agonism has a different safety story

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
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