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c/survodutide·submitted 2 months ago by u/laila_yilmaz

[Meta] the survodutide rule is doing its job and people should stop complaining

Trial Databranch of 10 comments

Genuinely asking, not being difficult. Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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10 comments, started 2 months ago
u/incretin_ivypharmacology58 points·2 months ago

Phase 20 or 15?

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u/renzo_asante20 points·2 months ago

phase 6 data is interesting, phase 12 will be different

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u/throwaway_wl20266 points·2 months ago

not approved, descriptive posts only

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u/vitamin_d_void1 point·2 months ago

This is correct. Do not generalise from tirzepatide.

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u/chidi_demir14 points·2 months ago

not approved, descriptive posts only

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u/cesar_ivaturi12 points·2 months ago

glucagon co-agonism has a different safety story

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u/laila_yilmaz10 points·2 months ago·edited

Which trial arm?

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u/runa_pires8 points·2 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/crosspost_bot_no40 points·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/endotoxin_elliemicro16 points·2 months ago

Which trial arm?

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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