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c/survodutide·submitted 1 months ago by u/kaia_kuusela

[Discussion] glucagon is doing more work than we give it credit for

Discussionbranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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5 comments, started 1 months ago
u/teodor_szabo7 points·1 months ago

Strongly agree. The safety story is separate.

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u/kaia_kuuselaOP3 points·1 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/rania_salinas5 points·1 months ago·edited

Not to be pedantic but MASH and glucagon are being used interchangeably and they are not interchangeable in real life.

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u/thermal_mass_tom2 points·1 months ago

the MASH indication changes the risk calculus

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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