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c/survodutide·submitted 1 months ago by u/marisol_frisk

glucagon is the most under-discussed thing in c/scamalerts

Paperbranch of 7 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers…

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7 comments, started 1 months ago
u/liver_enzyme_liz13 points·1 months ago·edited

Mechanistically the bit that matters is glucagon. It explains most of the early profile and a decent chunk of the outcome.

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u/teodor_szabo9 points·1 months ago

the MASH indication changes the risk calculus

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u/preservative_free_p3 points·1 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/heart_rate_bump2 points·1 months ago·edited

phase 8 data is interesting, phase 25 will be different

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u/cesar_ivaturi1 point·1 months ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/incretin_ivypharmacology5 points·1 months ago

the heart rate signal is real in the data

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u/clara_restrepo1 point·1 months ago

Phase 15 or 13?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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