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c/tirzepatide·submitted 2 years ago by u/aksel_kjaer

tried tirzepatide for 15 weeks. here is what happened.

Titrationbranch of 9 comments

Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 15, sulphur burps present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 23 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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This branch

9 comments, started 2 years ago
u/piotr_nascimento143 points·2 years ago·edited
saved. thank you.
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u/adnan_nascimento49 points·2 years ago

Hard agree. The food noise disappears differently on the two compounds.

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u/zeynep_zielinski39 points·2 years ago·edited

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/zaid_balogun39 points·2 years ago

the fatigue from tirz is different, not necessarily worse

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u/hub_opssite staff18 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/forest_plot_fionastats9 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/matias_salgado41 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/mikkel_kimani21 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

Yes, exactly this, and it is the bit that took me 22 weeks to accept.

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u/ghrp_history13 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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