genuine question about SURMOUNT that I am slightly embarrassed to ask
Confession thread, sort of.
I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 26 reads it before doing the same thing.
best — the order this archive was captured in
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Disagree but this is the good kind of wrong — it is specific enough to be checked.
press release SURMOUNT posts must be flaired until a publication exists
phase 2 is not phase 3, smaller n and shorter trial
SELECT reported a SELECT hazard ratio but the absolute event rate is what changes clinical practice.
phase 2 is not phase 3, smaller n and shorter trial
the discontinuation arms are the interesting part, not the FLOW endpoints
Not to be pedantic but TRIUMPH and STEP are being used interchangeably and they are not interchangeable in real life.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.
The confident tone is doing a lot of work that the evidence is not.
dropout handling matters, especially on GI-heavy populations
absolute risk reduction, not relative risk reduction, that is how you decide
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
press release hazard ratio posts must be flaired until a publication exists
- 1STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix9 comments in this branch · started by u/aurel_mwangi
- 2The confident tone is doing a lot of work that the evidence is not.4 comments in this branch · started by u/gastric_emptying_g