[Results] 81 weeks on 12.5mg, full numbers, ask me anything boring
Right, the TRIUMPH question again, but with numbers this time.
I have 11 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 70, not week 24. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
I am going to push back on this slightly.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
event rates are more informative than hazard ratios alone
number-needed-to-treat is the house dialect
I am going to push back on this slightly.
Disagree on that part. 98.1% and 99.3% on the same vial is normal.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Every time this gets posted it hits the front page and every time someone has to re-explain it.
off-label use data is different from approved-indication data
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Phase 2 TRIUMPH looked amazing.
Adding to this: hazard ratio is doing more work than the comment implies.
the discontinuation arms are the interesting part, not the endpoint endpoints
the relative risk reduction in headlines is not the whole story
This is correct. Discontinuation arms show the regain reality.
This is correct.
Disagree on that part. 96.8% and 96.2% on the same vial is normal.
This is correct. Discontinuation arms show the regain reality.
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
Not to be pedantic but SURMOUNT and endpoint are being used interchangeably and they are not interchangeable in real life.
You have restated the marketing copy. What is the actual substance here.
off-label use data is different from approved-indication data
I am going to push back on this slightly.
- 1Every time this gets posted it hits the front page and every time someone…9 comments in this branch · started by u/week_four_wall
- 2This is correct. Discontinuation arms show the regain reality.6 comments in this branch · started by u/sofia_wikstrom