u/injection_site_iris

the relative risk reduction in headlines is not the whole story

the heart rate signal is real in the data

private plan details: redact your group number

Strongly agree. Phase 2 is investigational, not conclusive.

the weight curves are unusually steep, which makes predicting individual response harder

Which trial arm and what was the n?

Yeah, the evidence standard works.

research use only, handling and analysis, not protocols

Sceptical. If this were true we would see it reflected in the data and we do not.

That is net peptide content, not purity. Different number, different meaning.

rodent survodutide is investigation only

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

Did you actually measure heart rate or is that a feeling?

What was the dropout rate?

the discontinuation arms are the interesting part, not the endpoint endpoints

the weight curves are unusually steep, which makes predicting individual response harder

What was the dosing schedule in that arm?

Dead space in the needle hub holds a small but non-trivial volume.

Yes, exactly this, and it is the bit that took me 53 weeks to accept.