u/zeynep_ndiaye

The confident tone is doing a lot of work that the evidence is not.

I am going to push back on this slightly.

small molecule, not a peptide, purity discussion is different

Came off after 89 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

SURMOUNT data is messier than STEP data but the weight loss is there

dual agonism is 15mg, do not generalise from semaglutide

Peak temperature and how long at that temperature?

glucagon co-agonism has a different safety story

the early fullness from tirz is different, not necessarily worse

Cite the TGA notice?

stability after excursion is not zero, it is dose-dependent

This matches the trial data. SURMOUNT-1 was 97.9% body weight at 2 weeks.

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

REDEFINE readouts are phase 8 data

This is correct. The the food-noise thing is horrible for three weeks and then just ends.

the supply conversation changes if this approves

the GIP side does different things than the GLP-1 side, that is the point

not approved, descriptive posts only

say how long you were on and at what dose before taper

Disagree but this is the good kind of wrong — it is specific enough to be checked.