why does nobody talk about dose escalation
Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 6 weeks and cost roughly what I expected. The admin was worse than the…
Which trial arm and what was the n?
heart rate and dose escalation need actual measurements, not impressions
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Which trial arm and what was the n?
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
the glucagon component changes the side effect profile, not just the efficacy
the dosing is steep, the constipation reports are real, and nobody knows the human safety yet
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.