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c/retatrutide·posted 1 year ago by u/renzo_yildiz

tried phase 2 for 12 weeks. here is what happened.

Question Clean Column ×8

Right, the triple agonist question again, but with numbers this time.

I have 11 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 4, not week 53. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

328 up / 12 down96% upvoted23 commentsid 2ddh16 Jun 2025

23 comments

22 in this archive, depth 4

best — the order this archive was captured in

u/reta_and_regretMOD49 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/marit_laurent16 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/soren_nkemelu5 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/kofi_balogun19 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/renzo_yildizOP10 points·1 year ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/nadia_trevino20 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/cormac_roos40 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/naomi_erdogan11 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/mateusz_mensah7 points·1 year ago

Did you actually measure heart rate or is that a feeling?

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u/priya_weiss0 points·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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[removed]18 points·1 year ago

[removed by moderator]

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u/renzo_yildiz31 points·1 year ago
genuine question, not being difficult: how do you know
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u/titration_marshalmod · c/semaglutide25 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/aa_analysis_andy23 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/cormac_roos6 points·1 year ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/renzo_yildizOP10 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/marit_laurent19 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/renzo_yildizOP15 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/rosa_almeida7 points·1 year ago·edited

the 2.5mg arm is different from 5mg, results do not transfer

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u/rui_only_ro12 points·1 year ago
this deserves more than 21 upvotes
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u/marta_vanhecke14 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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