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c/retatrutide·posted 4 months ago by u/matias_falk

[Lab] SSA reta — Medutest came back 97.4% against a claimed 96.2%

Lab Well Actually ×2 Slow Clap ×1

phase 2. That is the whole post, but I will justify it.

Everything else people worry about in c/glp1women is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does.

I say this having got it wrong for 10 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

1,621 up / 549 down75% upvoted64 commentsid tyylsg23 Mar 2026

64 comments

29 in this archive, depth 4

best — the order this archive was captured in

u/niels_lindqvist134 points·4 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/yannick_barros107 points·4 months ago

Did you actually measure heart rate or is that a feeling?

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u/cold_chromatogram_only0 points·4 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/ewan_marchand33 points·4 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/tired_ledger_notes103 points·4 months ago

Disagree. What you are describing is consistent with retatrutide, not with what you concluded.

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[removed]41 points·4 months ago

[removed by moderator]

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u/nikhil_lindqvist13 points·4 months ago

Not convinced. The evidence does not support that reading.

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u/reta_and_regretMOD70 points·4 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/matias_falkOP51 points·4 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/incretin_ivypharmacology24 points·4 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/matias_falkOP23 points·4 months ago

The glucagon component does different things than dual agonism. The injection-site soreness are not just amplified versions.

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u/nadia_norgaard0 points·4 months ago

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

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u/freya_baptista1 point·4 months ago·edited

Slight fix: the number was 99.0, not 98.9.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/kofi_balogun1 point·4 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/rui_only_ro25 points·4 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/farid_molnar-28 points·4 months ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/titration_marshalmod · c/semaglutide1 point·4 months ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/matias_falkOP1 point·4 months ago

triple agonism is glucagon, do not generalise

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u/divya_bakken1 point·4 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/bastian_ekstrom1 point·4 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/arne_amankwah1 point·4 months ago

Not to be pedantic but triple agonist and dose escalation are being used interchangeably and they are not interchangeable in real life.

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u/trialwatch_theotrial nerd1 point·4 months ago

Are you quoting phase 2 or is there phase 3 data now?

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u/rosa_almeida1 point·4 months ago

triple agonism is phase 2, do not generalise

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u/yannick_barros1 point·4 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/arne_amankwah26 points·4 months ago

I am going to push back on this slightly.

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u/signe_villalobos37 points·4 months ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/trialwatch_theotrial nerd13 points·4 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/careful_gradient329 points·4 months ago

triple agonism is glucagon, do not generalise

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u/kofi_balogun5 points·4 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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