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[Discussion] biopsy is doing more work than we give it credit for
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers…
Mechanistically the bit that matters is hepatic fat. It explains most of the early profile and a decent chunk of the outcome.
the MASH indication changes the risk calculus
MASH claims need the trial and the biopsy endpoint
Yeah, glucagon co-agonism is genuinely different.