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c/survodutide·submitted 4 months ago by u/thermal_mass_tom

biopsy is the most under-discussed thing in c/bloodwork

Questionbranch of 15 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers…

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15 comments, started 4 months ago
u/marisol_frisk52 points·4 months ago

phase 16 data is interesting, phase 24 will be different

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u/thermal_mass_tomOP21 points·4 months ago

phase 16 data is interesting, phase 24 will be different

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/julia_mensa6 points·4 months ago

rodent dual agonist is investigation only

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[deleted]20 points·4 months ago

[deleted]

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u/incretin_ivyMOD39 points·4 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/whois_wanda24 points·4 months ago

the MASH indication changes the risk calculus

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u/kian_ferreira17 points·4 months ago

glucagon co-agonism has a different safety story

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u/peak_area_peteanalytical6 points·4 months ago·edited

Which trial arm?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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