[Discussion] we are measuring Zepbound at the wrong time and calling it noise
Posting this because I searched for it and got nothing useful.
Setup: 2.5mg, week 84, sulphur burps present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 9 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
Crossposting this to c/compounding because the people who need it are not reading this community.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
the 15mg is the top of the pen, not the required dose
This matches the trial data. SURMOUNT-1 was 99.3% body weight at 9 weeks.
This is an urgent-care question wearing a forum question's clothes.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the 15mg is the top of the pen, not the required dose
The confident tone is doing a lot of work that the evidence is not.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
the 15mg is the top of the pen, not the required dose
You have restated the marketing copy. What is the actual substance here.
the fatigue from tirz is different, not necessarily worse
Did the constipation feel the same as on tirz or genuinely different?
Zepbound and Mounjaro are literally the same drug, the name is the only difference
That is net peptide content, not purity. Different number, different meaning.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
SURMOUNT data is messier than STEP data but the weight loss is there
Sceptical. If this were true we would see it reflected in the data and we do not.
Is that on Mounjaro pens or research tirzepatide?
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Did the muscle cramps feel the same as on tirz or genuinely different?
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Sceptical. If this were true we would see it reflected in the data and we do not.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
SURMOUNT data is messier than STEP data but the weight loss is there
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 22 weeks.
- 1Dead space in the needle hub holds a small but non-trivial volume. On…10 comments in this branch · started by u/halima_boateng
- 2SURMOUNT data is messier than STEP data but the weight loss is there7 comments in this branch · started by u/coring_the_stopper