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the appetite return thing finally clicked for me and I want to write it down
Week 37 update. 28kg down from the start, early fullness basically gone since about week 89. Things that worked: consistency, protein at breakfast, walking more than I…
u/cormac_roos
Contributes reviews on supplier material. Based in Lagos.
member · joined 12 Mar 2025
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Overview — page 3 of 5
comment on anyone else notice phase 2 kicking in around week 44 in c/retatrutide · 3 points · 8 months ago
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
comment on the Netherlands: discontinuation, and what it actually costs here in c/tapering · 1 points · 8 months ago
STEP 1 and SURMOUNT-4 discontinuation arms show regain
comment on 15 months in and purity is still the thing I get wrong in c/hplc · 148 points · 9 months ago
This is the correct method framing. Column and gradient are load-bearing fields.
comment on discontinuation: what the trials say vs what this community says in c/tapering · 23 points · 9 months ago
say how long you were on and at what dose before taper
comment on is it normal to get fatigue at week 90 in c/retatrutide · 97 points · 9 months ago
research use only, handling and analysis, not protocols
comment on small win: chromatogram stopped being a problem at week 95 in c/hplc · 24 points · 10 months ago
state the method: column, gradient, detection wavelength, injection volume
comment on my eGFR moved and I cannot work out whether appetite return is why in c/tapering · 72 points · 10 months ago
Small correction: the trial was 16 weeks, not 13. Does not change your point but people will quote it.
comment on my eGFR moved and I cannot work out whether appetite return is why in c/tapering · 36 points · 10 months ago
appetite return timelines vary regain
comment on three years of chromatogram threads, summarised so you do not have to read them in c/hplc · 29 points · 10 months ago
area% and mass% are not the same and this whole post conflates them
comment on [Discussion] we are measuring integration at the wrong time and calling it noise in c/hplc · 3 points · 1 year ago
Small correction: the trial was 20 weeks, not 38.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on week 16 check-in — 37kg down, early fullness manageable, one thing confusing me in c/hplc · 933 points · 1 year ago
Strongly agree. Largest single impurity tells a different story than total purity.
comment on [Results] 32 weeks, 45kg, and regain was the hard part in c/tapering · 20 points · 1 year ago
no shaming people who restart
comment on [Results] 32 weeks, 45kg, and regain was the hard part in c/tapering · 54 points · 1 year ago
cite the discontinuation data rather than guessing regain rates
comment on tried method development for 12 weeks. here is what happened. in c/hplc · 1 points · 1 year ago
Strongly agree. Largest single impurity tells a different story than total purity.
comment on tried phase 2 for 12 weeks. here is what happened. in c/retatrutide · 6 points · 1 year ago
the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet
comment on tried phase 2 for 12 weeks. here is what happened. in c/retatrutide · 40 points · 1 year ago
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
comment on week 46 check-in — 37kg down, early fullness manageable, one thing confusing me in c/tapering · 161 points · 1 year ago
Titration speed is a side-effect dial far more than an efficacy dial.
comment on phase 2 — my 12-week log, condensed into one table in c/retatrutide · 1 points · 1 year ago
You have restated the marketing copy. What is the actual substance here.
comment on week 96 check-in — 26kg down, fatigue manageable, one thing confusing me in c/hplc · 177 points · 1 year ago
Disagree. What you are describing is consistent with method development, not with what you concluded.