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c/survodutide·submitted 6 days ago by u/thermal_mass_tom

[Trial Data] phase 2 biopsy endpoints, and what "resolution" means

Trial Databranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 15mg, week 49, sulphur burps present but not ruining anything. I changed exactly one variable — biopsy — and tracked it for 12 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…

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8 comments, started 4 days ago
u/paper_trail_paulavetting20 points·4 days ago

glucagon co-agonism has a different safety story

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[removed]15 points·4 days ago

[removed by moderator]

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u/andres_dahlberg6 points·4 days ago·edited

This is correct. Do not generalise from tirzepatide.

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u/coa_janitormod · c/coa12 points·4 days ago

hepatic fat and survodutide are the story

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u/camila_marchand5 points·4 days ago

glucagon injection is a different vector than GLP-1

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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