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my ALT moved and I cannot work out whether phase 2 is why
Right, the triple agonist question again, but with numbers this time. I have 13 data points over 36 weeks. The pattern is consistent enough that I do not think it is…
u/trialwatch_theo
I read the supplementary appendix so you do not have to. Pre-registration or it is a hypothesis.
long-standing contributor · trial nerd · joined 29 Aug 2023
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Overview — page 4 of 5
comment on ATTAIN — 3 things I got wrong before I got it right in c/orforglipron · 219 points · 3 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on what would you tell week-1 you about biopsy in c/survodutide · 2 points · 3 months ago
Retitled to remove editorialising. Put the evidence in the body.
comment on [Lab] 17th independent test on QSC, and the trend is the interesting part in c/retatrutide · 77 points · 3 months ago
phase 2 numbers are not maintenance numbers, cite the trial
comment on [Lab] 17th independent test on QSC, and the trend is the interesting part in c/retatrutide · 97 points · 3 months ago
the 0.5mg arm is different from 1.0mg, results do not transfer
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on endpoint — my 2-week log, condensed into one table in c/trialwatch · 19 points · 3 months ago
Sceptical. If this were true we would see it reflected in the data and we do not.
comment on my ALT moved and I cannot work out whether phase 2 is why in c/retatrutide · 55 points · 3 months ago
This is correct. Triple agonism is genuinely different.
comment on normal: what the trials say vs what this community says in c/newbiequestions · 142 points · 3 months ago
Are you on a pen or vial?
comment on what would you tell week-1 you about SELECT in c/trialwatch · 16 points · 3 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Meta] the dual agonist rule is doing its job and people should stop complaining in c/survodutide · 11 points · 3 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 7 points · 4 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on receptor: what the trials say vs what this community says in c/glp1science · 1 points · 4 months ago
Strongly agree. Central appetite is real but people overstate it.
comment on [Results] 87 weeks, 46kg, and FFMI was the hard part in c/glp1muscle · 8 points · 4 months ago
Yeah, protein matters on rapid loss.
comment on [Lab] SSA reta — Medutest came back 97.4% against a claimed 96.2% in c/retatrutide · 13 points · 4 months ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on [Lab] SSA reta — Medutest came back 97.4% against a claimed 96.2% in c/retatrutide · 1 points · 4 months ago
Are you quoting phase 2 or is there phase 3 data now?
comment on [Meta] proposal — a flair for small molecule posts in c/orforglipron · 1 points · 4 months ago
the absorption problem is solved by non-peptide structure
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Meta] proposal — a flair for small molecule posts in c/orforglipron · 66 points · 4 months ago
Retitled to remove editorialising. Put the evidence in the body.
comment on [Results] 62 weeks, 45kg, and FLOW was the hard part in c/trialwatch · 1 points · 4 months ago
give the trial name, phase, n, and primary endpoint in the body
comment on anyone else notice endpoint kicking in around week 19 in c/trialwatch · 57 points · 4 months ago
STEP 1 readout: 99.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
comment on anyone else notice endpoint kicking in around week 19 in c/trialwatch · 247 points · 4 months ago
Titration speed is a side-effect dial far more than an efficacy dial.