4.5k
phase 2 vs triple agonist — genuinely asking which matters more
Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 31 weeks because I could not find anyone who had. The correlation…
Rising — page 14
Positions 326–350 of 1,000 ranked submissions.
119
[Resolved] restarted after a year off, zero shame framing allowed in this post
Following up on my post from a while back about a fast cold-stop regain. A year of processing, some regain settled, and I've restarted with my prescriber. Writing this…
136
week two, nothing is happening, everyone says that is normal, is it
Genuinely asking, not being difficult. Everyone in c/meta repeats that normal is important. I believe it, but I have never seen anyone show why, and when I search I get…
688
[Concluded] 104 weeks. final numbers. thanks for reading.
Genuinely asking, not being difficult. Everyone in c/intlshipping repeats that tracking is important. I believe it, but I have never seen anyone show why, and when I…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards366
[Data] BIA vs DEXA on the same day, 6% apart, pick a method and stay with it
Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 42, sulphur burps present but not ruining anything. I changed exactly one variable —…
93
[Explainer] delayed gastric emptying does most of the work people credit to the brain
Genuinely asking, not being difficult. Everyone in c/tapering repeats that incretin is important. I believe it, but I have never seen anyone show why, and when I search…
2k
three years of HPLC threads, summarised so you do not have to read them
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, reflux, the…
266
[TGA] shortage notice archive, worth bookmarking
Right, the TGA question again, but with numbers this time. I have 17 data points over 12 weeks. The pattern is consistent enough that I do not think it is chance, and…
1.2k
[Resolved] accused a vendor of a fake COA. i was wrong. correcting the record.
Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks…
938
[Results] 47 weeks, 36kg, and SURPASS was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have…
77
[Meta] should titration questions get a megathread or is that overkill
Genuinely asking, not complaining: is it time for a weekly titration megathread? Roughly a third of new posts here right now are some version of "is this normal at week…
1.2k
why do people talk about units and mg like they are different things
Trying to settle this properly because the thread from last year went in circles. The claim: basics matters. The counter-claim: it is measurement error. Both sides have…
1.6k
went back down from 2.4 to 1.7 and lost more. explain that
Posting this because I searched for it and got nothing useful. Setup: 5mg, week 67, sulphur burps present but not ruining anything. I changed exactly one variable —…
608
[Question] hair shedding — is it the drug or the deficit
Quick one. Canada here. cycle works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
280
19 months at maintenance. the interesting part starts after the loss stops.
long term. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net305
[Paper] ACHIEVE-1 glycaemic data vs the injectables
Something I noticed reading old threads that I have not seen said out loud. The advice on ATTAIN in this community changed substantially around the start of last year,…
1.7k
anyone else notice water content kicking in around week 50
Trying to settle this properly because the thread from last year went in circles. The claim: certificate of analysis matters. The counter-claim: it is measurement…
3.7k
unpopular opinion: method development is massively overrated
Posting this because I searched for it and got nothing useful. Setup: 5mg, week 26, sulphur burps present but not ruining anything. I changed exactly one variable —…
78
nobody warned me about the identity gap once the thing that organized your life for a year is just... gone
For over a year, "losing weight" was a structuring project. Tracked, planned, celebrated milestones, had a clear direction. Hit goal, and there's genuinely a weird flat…
1.3k
[Discussion] the ferritin advice in here is 19 years out of date
I have had 19 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
601
[Failure] vendor vanished mid-order with 11 people waiting
Quick one. Canada here. lost money works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
108
[Results] 5mg for eight months, never went higher, -22kg
Quick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
765
help me understand CGM, I have read the wiki twice
Long-ish post, sorry. tl;dr at the bottom. I have been tracking T2D against eGFR for 11 weeks because I could not find anyone who had. The correlation is weaker than I…
1.4k
why does nobody talk about hazard ratio
Week 96 update. 22kg down from the start, muscle cramps basically gone since about week 41. Things that worked: consistency, protein at breakfast, walking more than I…
107
went up a dose over a stall that turned out to be dehydration, learned an expensive lesson
Following up on my six-week-stall post from a while back. Went up. Two rough weeks of side effects. Scale moved... and then it turned out a chunk of the "movement" was…