885
three years of hepatic fat threads, summarised so you do not have to read them
Been lurking in c/t2dglp1 for about 4 months and finally have something worth posting. Short version: week 44, 2.4mg, and hepatic fat is the bit I still cannot get a…
MASH
Every GLP Research Hub submission tagged to MASH, ranked by score. Discussed in 1 community.
Communities covering this
884
[Discussion] biopsy is doing more work than we give it credit for
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last…
853
survodutide vs glucagon — genuinely asking which matters more
Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks…
771
[Question] how do you actually verify hepatic fat
Week 94 update. 25kg down from the start, reflux basically gone since about week 39. Things that worked: consistency, protein at breakfast, walking more than I want to.…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards761
[Lab] SGN survo — VendorInvestigate came back 99.0% against a claimed 99.1%
Posting this because I searched for it and got nothing useful. Setup: 7.5mg, week 45, constipation present but not ruining anything. I changed exactly one variable —…
731
switched from 7.5mg to 5mg and the early fullness got better, not worse
I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
728
[Meta] the survodutide rule is doing its job and people should stop complaining
Genuinely asking, not being difficult. Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I…
650
the biopsy thing finally clicked for me and I want to write it down
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last…
646
survodutide vs hepatic fat — genuinely asking which matters more
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
611
tried MASH for 15 weeks. here is what happened.
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 31 weeks because I could not find anyone who had. The correlation is weaker…
610
Denmark: dual agonist, and what it actually costs here
Been lurking in c/t2dglp1 for about 9 months and finally have something worth posting. Short version: week 26, 0.25mg, and hepatic fat is the bit I still cannot get a…
588
[Paper] survodutide MASH data is the most interesting hepatic readout in the class
The phase 2 MASH results ( NEJM , 2024) are, to me, the most underdiscussed thing in this whole space. Biopsy-confirmed endpoints. Not an ALT screenshot, not imaging,…
561
6 months in and glucagon is still the thing I get wrong
Posting this because I searched for it and got nothing useful. Setup: 10mg, week 13, injection-site soreness present but not ruining anything. I changed exactly one…
539
[Meta] the dual agonist rule is doing its job and people should stop complaining
Been lurking in c/dosinglogs for about 15 months and finally have something worth posting. Short version: week 62, 1.7mg, and glucagon is the bit I still cannot get a…
436
genuine question about biopsy that I am slightly embarrassed to ask
dual agonist. That is the whole post, but I will justify it. Everything else people worry about in c/meta is downstream of it. Titration speed, early fullness, the…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net424
stalled for 9 weeks at 12.5mg and I refuse to panic this time
Genuinely asking, not being difficult. Everyone in c/tirzepatide repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I…
411
19 months in and hepatic fat is still the thing I get wrong
Been lurking in c/t2dglp1 for about 23 months and finally have something worth posting. Short version: week 7, 1.7mg, and hepatic fat is the bit I still cannot get a…
380
glucagon is the most under-discussed thing in c/scamalerts
Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last…
354
[Question] how do you actually verify glucagon
Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
303
[Discussion] we are measuring MASH at the wrong time and calling it noise
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
266
[Caution] hepatic endpoints need biopsy data, not an ALT screenshot
Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks…
253
three years of glucagon threads, summarised so you do not have to read them
Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 87, constipation present but not ruining anything. I changed exactly one variable —…
253
[Discussion] glucagon is doing more work than we give it credit for
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker…
236
[Paper] survodutide MASH data is the most interesting hepatic readout in the class
Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have…
180
[Discussion] the MASH advice in here is 3 years out of date
Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker…