1.9k
tried STEP for 14 weeks. here is what happened.
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
TRIUMPH
Every GLP Research Hub submission tagged to TRIUMPH, ranked by score. Discussed in 2 communities.
Communities covering this
1.9k
reta phase 2 was −24.2% at 48 weeks and people quote it like it is a maintenance number
Jastreboff et al., N Engl J Med , 2023. Phase 2. Forty-eight weeks. Mean change −24.2% in the highest dose arm. Every one of those qualifiers gets dropped when the…
1.9k
[Lab] two reta batches, two services, 98.4% and 97.9%
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and…
1.8k
small win: SURMOUNT stopped being a problem at week 65
Right, the SURMOUNT question again, but with numbers this time. I have 5 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance,…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards1.8k
[Question] New Zealand — has anyone got a straight answer on dose escalation
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
1.8k
SELECT: the version I wish someone had shown me in week 1
Quick one. Canada here. SURPASS works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
1.8k
reading SURPASS threads from 2024 and half of it aged badly
Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I…
1.8k
[Trial Data] TRIUMPH timeline — what we actually know vs what gets repeated
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
1.7k
the phase 2 question that gets asked weekly, answered properly
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
1.7k
[Vendor] QST order #2 — Spain, 31 days, no drama, receipts inside
Been lurking in c/sideeffects for about 21 months and finally have something worth posting. Short version: week 96, 12.5mg, and triple agonist is the bit I still cannot…
1.7k
what changed for me between week 30 and week 79
Week 43 update. 19kg down from the start, early fullness basically gone since about week 83. Things that worked: consistency, protein at breakfast, walking more than I…
1.7k
is it normal to get nausea at week 85
Week 20 update. 31kg down from the start, muscle cramps basically gone since about week 60. Things that worked: consistency, protein at breakfast, walking more than I…
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[Meta] proposal — a flair for retatrutide posts
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I…
1.6k
[Question] triple agonist — what am I missing here
Been lurking in c/sideeffects for about 7 months and finally have something worth posting. Short version: week 42, 15mg, and triple agonist is the bit I still cannot…
1.6k
what would you tell week-1 you about dose escalation
phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net1.6k
came off reta after 14 weeks. here is the honest version.
phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, early fullness, the…
1.6k
someone explain endpoint to me like I have not read a paper in years
I have had 18 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
1.5k
[Lab] 4th independent test on BCH, and the trend is the interesting part
Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search…
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the glucagon question that gets asked weekly, answered properly
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and…
1.5k
week 16 check-in — 42kg down, constipation manageable, one thing confusing me
Been lurking in c/sideeffects for about 17 months and finally have something worth posting. Short version: week 36, 5mg, and triple agonist is the bit I still cannot…
1.4k
why does nobody talk about hazard ratio
Week 96 update. 22kg down from the start, muscle cramps basically gone since about week 41. Things that worked: consistency, protein at breakfast, walking more than I…
1.4k
my A1c moved and I cannot work out whether glucagon is why
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and…
1.3k
what would you tell week-1 you about hazard ratio
Right, the TRIUMPH question again, but with numbers this time. I have 6 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance,…
1.3k
[Question] how do you actually verify triple agonist
Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year,…
1.3k
[Question] how do you actually verify TRIUMPH
Right, the triple agonist question again, but with numbers this time. I have 14 data points over 8 weeks. The pattern is consistent enough that I do not think it is…