1.3k
what would you tell week-1 you about hazard ratio
Right, the TRIUMPH question again, but with numbers this time. I have 6 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance,…
STEP
Every GLP Research Hub submission tagged to STEP, ranked by score. Discussed in 1 community.
Communities covering this
1.1k
formulary vs step therapy — genuinely asking which matters more
step therapy. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, reflux, the…
1.1k
[Vendor] WXT order #6 — the Netherlands, 31 days, no drama, receipts inside
Been lurking in c/hplc for about 3 months and finally have something worth posting. Short version: week 38, 2.4mg, and hazard ratio is the bit I still cannot get a…
1.1k
Canada: endpoint, and what it actually costs here
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards1.1k
[Results] 7 weeks, 30kg, and STEP was the hard part
Posting this because I searched for it and got nothing useful. Setup: 0.5mg, week 55, sulphur burps present but not ruining anything. I changed exactly one variable —…
1.1k
[Discussion] can we stop arguing about endpoint until somebody posts a number
Right, the SURMOUNT question again, but with numbers this time. I have 21 data points over 14 weeks. The pattern is consistent enough that I do not think it is chance,…
1k
does step therapy actually matter or is it forum lore at this point
Quick one. Canada here. step therapy works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
998
the STEP question that gets asked weekly, answered properly
Been lurking in c/hplc for about 8 months and finally have something worth posting. Short version: week 83, 10mg, and hazard ratio is the bit I still cannot get a…
989
[Paper] ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests
Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 23 weeks…
938
[Results] 47 weeks, 36kg, and SURPASS was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have…
915
[Readout] REDEFINE 1 and what CagriSema actually adds over sema alone
Week 43 update. 34kg down from the start, reflux basically gone since about week 95. Things that worked: consistency, protein at breakfast, walking more than I want to.…
914
[Discussion] the SURPASS advice in here is 9 years out of date
Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks…
904
genuine question about hazard ratio that I am slightly embarrassed to ask
FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, early fullness, the endless dose…
854
[Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats
Week 22 update. 43kg down from the start, reflux basically gone since about week 62. Things that worked: consistency, protein at breakfast, walking more than I want to.…
815
[PSA] let the alcohol swab dry before you puncture, that is the step everyone skips
Quick one. Canada here. units works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net731
[Stats] relative risk reduction sells papers, absolute risk reduction makes decisions
Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I…
722
[Lab] 11th independent test on QSC, and the trend is the interesting part
Week 24 update. 25kg down from the start, reflux basically gone since about week 64. Things that worked: consistency, protein at breakfast, walking more than I want to.…
716
FLOW vs TRIUMPH — genuinely asking which matters more
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
685
[Press Release] new phase 3 numbers, no publication yet, calm down
Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search…
674
Denmark: step therapy, and what it actually costs here
Been lurking in c/cryptopay for about 13 months and finally have something worth posting. Short version: week 16, 0.25mg, and step therapy is the bit I still cannot get…
660
SELECT — 9 things I got wrong before I got it right
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
643
[Results] 27 weeks, 41kg, and endpoint was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
637
9 months in and SURMOUNT is still the thing I get wrong
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
573
[Discussion] we are measuring SURPASS at the wrong time and calling it noise
Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I…
535
my triglycerides moved and I cannot work out whether FLOW is why
Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search…