520
[Stats] the placebo arm lost weight too. always ask by how much.
Right, the SURMOUNT question again, but with numbers this time. I have 4 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance,…
STEP
Every GLP Research Hub submission tagged to STEP, ranked by score. Discussed in 1 community.
Communities covering this
489
[Stats] number needed to treat, or i am not interested
I have had 15 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
479
18 months in and TRIUMPH is still the thing I get wrong
Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year,…
476
small win: TRIUMPH stopped being a problem at week 45
Week 32 update. 43kg down from the start, reflux basically gone since about week 84. Things that worked: consistency, protein at breakfast, walking more than I want to.…
PeptideMeter — community peptide analytics
Vendor-level purity averages over time, built from independent results rather than vendor claims. Transparent methodology, open dataset.
Browse results472
unpopular opinion: step therapy is massively overrated
denial. That is the whole post, but I will justify it. Everything else people worry about in c/meta is downstream of it. Titration speed, reflux, the endless dose…
456
[Question] step therapy — how do i document failing something cheaper
Genuinely asking, not being difficult. Everyone in c/labresults repeats that formulary is important. I believe it, but I have never seen anyone show why, and when I…
438
does FLOW actually matter or is it forum lore at this point
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
414
[Meta] proposal — a flair for SURPASS posts
Posting this because I searched for it and got nothing useful. Setup: 1.7mg, week 59, injection-site soreness present but not ruining anything. I changed exactly one…
400
someone explain step therapy to me like I have not read a paper in years
Something I noticed reading old threads that I have not seen said out loud. The advice on prior authorization in this community changed substantially around the start…
390
why does nobody talk about SELECT
Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year,…
374
[Log] eight weeks in, here’s the actual schedule and what each step felt like
Posting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…
363
watch where the curves separate, not just whether they do
Week 19 update. 10kg down from the start, early fullness basically gone since about week 71. Things that worked: consistency, protein at breakfast, walking more than I…
336
[Results] 87 weeks, 36kg, and endpoint was the hard part
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
326
step therapy — 16 things I got wrong before I got it right
Right, the external review question again, but with numbers this time. I have 20 data points over 32 weeks. The pattern is consistent enough that I do not think it is…
320
[Meta] the endpoint rule is doing its job and people should stop complaining
I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards305
[Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
298
reading STEP threads from 2024 and half of it aged badly
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
287
FLOW got published and nobody in here is talking about eGFR slope
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
275
[Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed
Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks…
266
step therapy is the most under-discussed thing in c/labresults
Quick one. Canada here. prior authorization works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently…
247
[Discussion] can we stop arguing about STEP until somebody posts a number
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
242
step therapy: the version I wish someone had shown me in week 1
Quick one. Canada here. external review works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
233
intent-to-treat vs per-protocol explains half the arguments on this site
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have…
191
help me understand FLOW, I have read the wiki twice
FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, reflux, the endless dose…
183
genuine question about SELECT that I am slightly embarrassed to ask
Week 45 update. 16kg down from the start, reflux basically gone since about week 85. Things that worked: consistency, protein at breakfast, walking more than I want to.…